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Copenhagen Center for Glycomics (CCG) takes a genetic approach to explore and map the function of glycans. Precise genetic engineering via CRISPR/Cas9, Zinc finger Nucleases and TALENs is applied to interrogate the structure and function of glycogenes, and to precisely engineer cells with specific glycosylation capacities. By deconstructing, assigning and manipulating the glycosylation machinery in mammalian cells, we aim to understand how glycans impinge on the biology of cells during tissue formation, inflammation, immunity and cancer growth, and how this can be exploited for early detection and treatment of disease.

Glycosylation, Glycans, O-glycans, complex carbohydrates, precise genetic engineering, CRISPR, genetically modified organisms, GMO, GalNac Transferases, posttranslational modifications, cell factories, cancer, CAR, mucins, MUC1, Maersk Tower, Panum, University of Copenhagen, Biomedical research, Biotechnology, mass spetrometry