20 November 2020
New Publication in Chemical Communications
Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody
Authors: Francisco Corzana, Ramon Hurtado-Guerrero, Javier Macías-León, Iris A. Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho, Vincenzo Mangini, Inês S. Albuquerque, Filipa Marcelo, Juan Luis Asensio, Gonçalo J. L. Bernardes, Hiren J. Joshi, Roberto Fiammengo and Ola Blixt
Abstract:
The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is now disclosed. The antibody’s contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide mimetics for developing efficient anti-cancer vaccines and diagnostic tools.
