Publications

Contribution to journal - Journal article

1. Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. Julia A Tree*, Jeremy E Turnbull*, Karen R Buttigieg, Michael J Elmore, Naomi Coombes, John Hogwood, Courtney J. Mycroft-West, Marcelo A. Lima, Mark A. Skidmore, Richard Karlsson, Yen-Hsi Chen, Yang Zhang, Cosma M Spalluto, Karl J Staples, Edwin A Yates, Elaine Gray, Dave Singh, Tom Wilkinson, Clive P Page, Miles W Carroll. (2020) British J Pharmacology (in press). *Joint first authors.
   
   
2. Synthesis detection, the 'Achilles heel' of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels. Bennett EP, Petersen BL, Johansen IE, Niu Y, Yang Z, Chamberlain CA, Met Ö, Wandall HH, and Frödin M. Nucleic Acids Research. 2020 Nov. DOI: 10.1093/nar/gkaa975.
   
   
3. A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation. Katrine T. Schjoldager*, Henrik Clausen* and Ramon Hurtado-Guerrero*. Molecular Cell 78(5):803-805. (Comment on Molecular Cell, Schumann et al. (2020). DOI: 10.1016/j.molcel.2020.05.019 *joint corresponding authorship.

4. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., Yang, Z., Torres, J. L., Golden, G. J., Bartels, P. L., Porell, R. N., Garretson, A. F., Laubach, L., Feldman, J., Yin, X., Pu, Y., Hauser, B. M., Caradonna, T. M., Kellman, B. P., Martino, C., Gordts, P., Chanda, S. K., Schmidt, A. G., Godula, K., Leibel, S. L., Jose, J., Corbett, K. D., Ward, A. B., Carlin, A. F., and Esko, J. D. (2020) Cell. https://doi.org/10.1016/j.cell.2020.09.033
   
   
5. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, Wang S, Zhang L, Zhang Y, Malicdan MC, Mao Y, Christoffersen C, Tabak LA, Schjoldager KT, Ten Hagen KG. Proc Natl Acad Sci U S A. 2019; 116(50):25196-25202.
   
   
6. O-glycan initiation directs distinct biological pathways and controls epithelial differentiation. / Bagdonaite, Ieva; Pallesen, Emil M. H.; Ye, Zilu; Vakhrushev, Sergey Y.; Marinova, Irina N.; Nielsen, Mathias I.; Kramer, Signe H.; Pedersen, Stine F.; Joshi, Hiren J.; Bennett, Eric P.; Dabelsteen, Sally; Wandall, Hans H. In: EMBO Reports, Vol. 21, No. 6, e48885, 2020.
   
   
7. Lessons learned from 40 novel PIGA patients and a review of the literature. / Bayat, Allan; Knaus, Alexej; Pendziwiat, Manuela; Afenjar, Alexandra; Stefan Barakat, Tahsin; Bosch, Friedrich; Callewaert, Bert; Calvas, Patrick; Ceulemans, Berten; Chassaing, Nicolas; Depienne, Christel; Endziniene, Milda; Ferreira, Carlos R.; Moura de Souza, Carolina Fischinger; Freihuber, Cécile; Ganesan, Shiva; Gataullina, Svetlana; Guerrini, Renzo; Guerrot, Anne Marie; Hansen, Lars; Jezela-Stanek, Aleksandra; Karsenty, Caroline; Kievit, Anneke; Kooy, Frank R.; Korff, Christian M.; Kragh Hansen, Johanne; Larsen, Martin; Layet, Valérie; Lesca, Gaetan; McBride, Kim L.; Meuwissen, Marije; Mignot, Cyril; Montomoli, Martino; Moore, Hannah; Naudion, Sophie; Nava, Caroline; Nougues, Marie Christine; Parrini, Elena; Pastore, Matthew; Schelhaas, Jurgen H.; Skinner, Steven; Szczałuba, Krzysztoł; Thomas, Ashley; Thomassen, Mads; Tranebjærg, Lisbeth; van Slegtenhorst, Marjon; Wolfe, Lynne A.; Lal, Dennis; Gardella, Elena; Bomme Ousager, Lilian; Brünger, Tobias; Helbig, Ingo; Krawitz, Peter; Møller, Rikke S. In: Epilepsia, Vol. 61, No. 6, 2020, p. 1142-1155.
   
   
8. INDEL detection, the 'Achilles heel' of precise genome editing : a survey of methods for accurate profiling of gene editing induced indels. / Bennett, Eric Paul; Petersen, Bent Larsen; Johansen, Ida Elisabeth; Niu, Yiyuan; Yang, Zhang; Chamberlain, Christopher Aled; Met, Özcan; Wandall, Hans H.; Frödin, Morten. In: Nucleic Acids Research, Vol. 48, No. 21, 2020, p. 11958-11981.
   
   

9. Mechanism and site of action of big dynorphin on ASIC1a. / Borg, Christian B.; Braun, Nina; Heusser, Stephanie A.; Bay, Yasmin; Weis, Daniel; Galleano, Iacopo; Lund, Camilla; Tian, Weihua; Haugaard-Kedström, Linda M.; Bennett, Eric P.; Lynagh, Timothy; Strømgaard, Kristian; Andersen, Jacob; Pless, Stephan A. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 13, 2020, p. 7447-7454.
   
   
10. Cell-Based Glycan Arrays — A Practical Guide to Dissect the Human Glycome. / Büll, Christian; Joshi, Hiren Jitendra; Clausen, Henrik; Narimatsu, Yoshiki. In: STAR Protocols, Vol. 1, No. 1, 100017, 2020.
    
    
11. PODO447 : a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin. / Canals Hernaez, Diana; Hughes, Michael R.; Dean, Pamela; Bergqvist, Peter; Samudio, Ismael; Blixt, Ola; Wiedemeyer, Katharina; Li, Yicong; Bond, Chris; Cruz, Eric; Köbel, Martin; Gilks, Blake; Roskelley, Calvin D.; McNagny, Kelly M. In: Journal for ImmunoTherapy of Cancer, Vol. 8, No. 2, e001128, 2020.
    
    
12. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. / Clausen, Thomas Mandel; Sandoval, Daniel R.; Spliid, Charlotte B.; Pihl, Jessica; Perrett, Hailee R.; Painter, Chelsea D.; Narayanan, Anoop; Majowicz, Sydney A.; Kwong, Elizabeth M.; McVicar, Rachael N.; Thacker, Bryan E.; Glass, Charles A.; Yang, Zhang; Torres, Jonathan L.; Golden, Gregory J.; Bartels, Phillip L.; Porell, Ryan N.; Garretson, Aaron F.; Laubach, Logan; Feldman, Jared; Yin, Xin; Pu, Yuan; Hauser, Blake M.; Caradonna, Timothy M.; Kellman, Benjamin P.; Martino, Cameron; Gordts, Philip L.S.M.; Chanda, Sumit K.; Schmidt, Aaron G.; Godula, Kamil; Leibel, Sandra L.; Jose, Joyce; Corbett, Kevin D.; Ward, Andrew B.; Carlin, Aaron F.; Esko, Jeffrey D. In: Cell, Vol. 183, No. 4, 2020, p. 1043-1057.e15.
    
    
13. Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model. / Dabelsteen, Sally; Pallesen, Emil M. H.; Marinova, Irina N.; Nielsen, Mathias I.; Adamopoulou, Maria; Rømer, Troels B.; Levann, Asha; Andersen, Mikkel M.; Ye, Zilu; Thein, David; Bennett, Eric P; Büll, Christian; Moons, Sam J.; Boltje, Thomas; Clausen, Henrik; Vakhrushev, Sergey Y.; Bagdonaite, Ieva; Wandall, Hans H. In: Developmental Cell, Vol. 54, No. 5, 2020, p. 669-684.e7.
    
    
14. Ser and Thr acceptor preferences of the GalNAc-Ts vary among isoenzymes to modulate mucin-type O-glycosylation. / Daniel, Earnest James Paul; Las Rivas, Matilde; Lira-Navarrete, Erandi; García-García, Ana; Hurtado-Guerrero, Ramon; Clausen, Henrik; Gerken, Thomas A. In: Glycobiology, Vol. 30, No. 11, 2020, p. 910-922.
    
    
15. A mutation map for human glycoside hydrolase genes. / Hansen, Lars; Husein, Diab M.; Gericke, Birthe; Hansen, Torben; Pedersen, Oluf; Tambe, Mitali A.; Freeze, Hudson H.; Naim, Hassan Y.; Henrissat, Bernard; Wandall, Hans H.; Clausen, Henrik; Bennett, Eric P. In: Glycobiology, Vol. 30, No. 8, 2020, p. 500-515.
    
    
16. Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy. / Hong, Senlian; Yu, Chenhua; Wang, Peng; Shi, Yujie; Cao, Weiqian; Cheng, Bo; Chapla, Digantkumar G.; Ma, Yuanhui; Li, Jie; Rodrigues, Emily; Narimatsu, Yoshiki; Yates, John R.; Chen, Xing; Clausen, Henrik; Moremen, Kelly W.; Macauley, Matthew Scott; Paulson, James C.; Wu, Peng. In: Angewandte Chemie - International Edition, 2020.
    
    
17. Engineering mammalian cells to produce plant-specific N-glycosylation on proteins. / Larsen, Joachim Steen; Karlsson, Richard Torbjorn Gustav; Tian, Weihua; Schulz, Morten Alder; Matthes, Annemarie; Clausen, Henrik; Petersen, Bent L; Yang, Zhang. In: Glycobiology, Vol. 30, No. 8, 2020, p. 528-538.
    
    
18. Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody. / Macías-León, Javier; Bermejo, Iris A; Asín, Alicia; García-García, Ana; Compañón, Ismael; Jiménez-Moreno, Ester; Coelho, Helena; Mangini, Vincenzo; Albuquerque, Inês S; Marcelo, Filipa; Asensio, Juan L; Bernardes, Gonçalo J L; Joshi, Hiren J; Fiammengo, Roberto; Blixt, Ola; Hurtado-Guerrero, Ramón; Corzana, Francisco. In: Chemical communications (Cambridge, England), Vol. 56, No. 96, 08.12.2020, p. 15137-15140.
    
    
19. An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles. / Madsen, Thomas D.; Hansen, Lasse H.; Hintze, John; Ye, Zilu; Jebari, Shifa; Andersen, Daniel B.; Joshi, Hiren J.; Ju, Tongzhong; Goetze, Jens P.; Martin, Cesar; Rosenkilde, Mette M.; Holst, Jens J.; Kuhre, Rune E.; Goth, Christoffer K.; Vakhrushev, Sergey Y.; Schjoldager, Katrine T. In: Nature Communications, Vol. 11, No. 1, 4033, 2020.
    
    
20. Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides. / Miller, Rebecca L; Guimond, Scott E; Schwörer, Ralf; Zubkova, Olga V; Tyler, Peter C; Xu, Yongmei; Liu, Jian; Chopra, Pradeep; Boons, Geert-Jan; Grabarics, Márkó; Manz, Christian; Hofmann, Johanna; Karlsson, Niclas G; Turnbull, Jeremy E; Struwe, Weston B; Pagel, Kevin. In: Nature Communications, Vol. 11, No. 1, 20.03.2020, p. 1481.
    
    
21. Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. / Møller, Sofie H; Mellergaard, Maiken; Madsen, Mikkel; Bermejo, Amaia V; Jepsen, Stine D; Hansen, Marie H; Høgh, Rikke I; Aldana, Blanca Irene; Desler, Claus; Rasmussen, Lene Juel; Sustarsic, Elahu G; Gerhart-Hines, Zachary; Daskalaki, Evangelia; Wheelock, Craig E; Hiron, Thomas K; Lin, Da; O'Callaghan, Christopher A; Wandall, Hans H; Andresen, Lars; Skov, Søren. In: Frontiers in Immunology, Vol. 11, 1968, 2020.
    
    
22. Investigating patterns of immune interaction in ovarian cancer : Probing the o‐glycoproteome by the macrophage galactose‐like c‐type lectin (mgl). / Napoletano, Chiara; Steentoft, Catharina; Battisti, Federico; Ye, Zilu; Rahimi, Hassan; Zizzari, Ilaria Grazia; Dionisi, Marco; Cerbelli, Bruna; Tomao, Federica; French, Deborah; D’amati, Giulia; Panici, Pierluigi Benedetti; Vakhrushev, Sergey; Clausen, Henrik; Nuti, Marianna; Rughetti, Aurelia. In: Cancers, Vol. 12, No. 10, 2841, 2020, p. 1-20.
    
    
23. Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides. / Sharma, Preeti; Marada, Venkata V V R; Cai, Qi; Kizerwetter, Monika; He, Yanran; Wolf, Steven P; Schreiber, Karin; Clausen, Henrik; Schreiber, Hans; Kranz, David M. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 26, 30.06.2020, p. 15148-15159.
    
    
24. Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function. / Zilmer, Monica; Edmondson, Andrew C.; Khetarpal, Sumeet A.; Alesi, Viola; Zaki, Maha S.; Rostasy, Kevin; Madsen, Camilla G.; Lepri, Francesca R.; Sinibaldi, Lorenzo; Cusmai, Raffaella; Novelli, Antonio; Issa, Mahmoud Y.; Fenger, Christina D.; Jamra, Rami Abou; Reutter, Heiko; Briuglia, Silvana; Agolini, Emanuele; Hansen, Lars; Petäjä-Repo, Ulla E.; Hintze, John; Raymond, Kimiyo M.; Liedtke, Kristen; Stanley, Valentina; Musaev, Damir; Gleeson, Joseph G.; Vitali, Cecilia; O’Brien, W. Timothy; Gardella, Elena; Rubboli, Guido; Rader, Daniel J.; Schjoldager, Katrine T.; Møller, Rikke S. In: Brain, Vol. 143, No. 4, 2020, p. 1114-1126.
    
    
25. Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3. / de las Rivas, Matilde; Paul Daniel, Earnest James; Narimatsu, Yoshiki; Compañón, Ismael; Kato, Kentaro; Hermosilla, Pablo; Thureau, Aurélien; Ceballos-Laita, Laura; Coelho, Helena; Bernadó, Pau; Marcelo, Filipa; Hansen, Lars; Maeda, Ryota; Lostao, Anabel; Corzana, Francisco; Clausen, Henrik; Gerken, Thomas A.; Hurtado-Guerrero, Ramon. In: Nature Chemical Biology, Vol. 16, 2020, p. 351–360.

Contribution to journal - Letter

26. Cryogenic Infrared Spectroscopy Reveals Structural Modularity in the Vibrational Fingerprints of Heparan Sulfate Diastereomers. / Lettow, Maike; Grabarics, Márkó; Greis, Kim; Mucha, Eike; Thomas, Daniel A.; Chopra, Pradeep; Boons, Geert Jan; Karlsson, Richard; Turnbull, Jeremy E.; Meijer, Gerard; Miller, Rebecca L.; Von Helden, Gert; Pagel, Kevin. In: Analytical Chemistry, Vol. 92, No. 15, 2020, p. 10228-10232.

Contribution to journal - Review

27. Global view of human protein glycosylation pathways and functions. / Schjoldager, Katrine T.; Narimatsu, Yoshiki; Joshi, Hiren J.; Clausen, Henrik. In: Nature Reviews Molecular Cell Biology, Vol. 21, 2020, p. 729–749.

Contribution to journal - Editorial

28. Upgrading hypertension treatment. / Goetze, Jens P.; Hansen, Lasse H.; Terzic, Dijana; Mark, Peter Dall. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 318, No. 6, 2020, p. R1025-R1026.

Contribution to journal - Conference abstract in journal

29. A Genetic Approach to Display and Dissect the Cancer-Associated O-Glycoepitome. / Clausen, Henrik; Nason, Rebecca; Mandel, Ulla; Narimatsu, Yoshiki. In: FASEB Journal, Vol. 34, No. S1, 2020.

Book/Report - Ph.D. thesis

30. Genetic Engineering of Glycosylation in Mammalian Cells - Installation of Sulfation Capacities. / Sun, Lingbo. Københavns Universitet, 2020.

1. Owen J, Thomas E, Menon J, Gray M, Skaripa-Koukelli I, Gill MR, Wallington S, Miller RL, Vallis KA, Carlisle R. Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation. J Control Release. 2019 Dec 28;319:222-233.

2. Graham JB, Sunryd JC, Mathavan K, Weir E, Larsen ISB, Halim A, Clausen H, Cousin H, Alfandari D, Hebert DN. ER transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, Cellular Adherence and Embryonic Gastrulation.  Mol Biol Cell. 2019 Dec 18

3. Johansen IE, Liu Y, Jørgensen B, Bennett EP, Andreasson E, Nielsen KL, Blennow A, Petersen BL. High efficacy full allelic CRISPR/Cas9 gene editing in tetraploid potato. Sci Rep. 2019 Nov 27;9(1):17715.

4. Tian E, Wang S, Zhang L, Zhang Y, Malicdan MC, Mao Y, Christoffersen C, Tabak LA, Schjoldager KT, Ten Hagen KG. (2019). Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Proc Natl Acad Sci USA Nov. doi.org/10.1073/pnas.1909573116
5. He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H. (2019). Multiple cancer-specific antigens are targeted by a chimeric antibody receptor on a single cancer cell. JCI Insight. 4. pii: 130416. doi:10.1172/jci.insight.130416
6. Clausen H, Olsson ML. (2019) Towards universally acceptable blood. Nat Microbiol. 4:1426-1427. doi: 10.1038/s41564-019-0548-9.
7. Ye Z, Mao Y, Clausen H, Vakhrushev SY. (2019). Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries. Nat Methods. 16:902-910. doi: 10.1038/s41592-019-0504-x.
8. Pedersen AML, Bukkehave KH, Bennett EP, Twetman S. (2019) Effect of Lozenges Containing Lactobacillus reuteri on the Severity of Recurrent Aphthous Ulcers: a Pilot Study. Probiotics Antimicrob Proteins. Aug 13. doi: 10.1007/s12602-019-09586-x.
9. Petersen BL, Möller SR, Mravec J, Jørgensen B, Christensen M, Liu Y, Wandall HH, Bennett EP, Yang Z. (2019). Improved CRISPR/Cas9 gene editing by fluorescence activated cell sorting of green fluorescence protein tagged protoplasts. BMC Biotechnol.;19:36. doi: 10.1186/s12896-019-0530-x.
10. Osborn MJ, Newby GA, McElroy AN, Knipping F, Nielsen SC, Riddle MJ, Xia L, Chen W, Eide CR, Webber BR, Wandall HH, Dabelsteen S, Blazar BR, Liu DR, Tolar J. (2019). Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs. J Invest Dermatol.  Aug 19. pii: S0022-202X(19)32698-3. doi: 10.1016/j.jid.2019.07.701.
11. Pedersen JW, Nøstdal A, Wandall HH. (2019). Multiplexed Detection of Autoantibodies to Glycopeptides Using Microarray. Methods Mol Biol. 2024:199-211. doi: 10.1007/978-1-4939-9597-4_12.
12. Steentoft C, Yang Z, Wang S, Ju T, Vester-Christensen MB, Festari MF, King SL, Moremen K, Larsen ISB, Goth CK, Schjoldager KT, Hansen L, Bennett EP, Mandel U, Narimatsu Y. (2019). A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation. Glycobiology 29:645-656. doi: 10.1093/glycob/cwz041.
13. Narimatsu Y, Joshi H, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen Y, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Bull C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H. (2019). An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells. Mol Cell 75: 1-14. DOI: 10.1016/j.molcel.2019.05.017
14. Hansen LH, Madsen TD, Goth CK, Clausen H, Chen Y, Dzhoyashvili N, Iyer SR, Sangaralingham SJ, Burnett JC Jr, Rehfeld JF, Vakhrushev SY, Schjoldager KT, Goetze JP. (2019) Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor. J Biol Chem.  pii: jbc.RA119.008102. doi: 10.1074/jbc.RA119.008102.
15. Rojas-Macias MA, Mariethoz J, Andersson P, Jin C, Venkatakrishnan V, Aoki NP, Shinmachi D, Ashwood C, Madunic K, Zhang T, Miller RL, Horlacher O, Struwe WB, Watanabe Y, Okuda S, Levander F, Kolarich D, Rudd PM, Wuhrer M, Kettner C, Packer NH, Aoki-Kinoshita KF, Lisacek F, Karlsson NG. 2019. Towards a standardized bioinformatics infrastructure for N- and O-glycomics. Nat Commun. 10:3275. doi: 10.1038/s41467-019-11131-x.
16. Willems AP, Sun L, Schulz MA, Tian W, Ashikov A, van Scherpenzeel M, Hermans E, Clausen H, Yang Z, Lefeber DJ. 2019. Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis. Biochim Biophys Acta Gen Subj. 1863:1471-1479. doi: 10.1016/j.bbagen.2019.05.011.
17. Narimatsu Y, Joshi H, Schjoldager KT, Halim A, Steentoft C, Mandel U, Bennett EP, Clausen H, Vakhrushev SY (2019): Exploring Regulation of Protein O-Glycosylation in Isogenic Human HEK293 Cells by Differential O-Glycoproteomics. Mol Cell Proteomics, 18:1396-1409; 
18. Tian W, Ye Z, Wang S, Schulz MA, Van Coillie J, Sun L, Chen Y-H, Narimatsu Y, Hansen L, Kristensen C, Mandel U, Bennett EP, Jabbarzadeh-Tabrizi S, Schiffmann R, Shen J-S, Vakhrushev SY, Clausen H, Yang Z. (2019) The Glycosylation Design Space for Recombinant Lysosomal Replacement Enzymes Produced in CHO Cells. Nat Commun. 10:1785. tps://doi.org/10.1038/s41467-019-098. (CO, PR, OA)
19. Larsen ISB, Narimatsu Y, Clausen H, Joshi HJ, Halim A. (2019) Multiple distinct O-Mannosylation pathways in eukaryotes. Curr Opin Struct Biol 56:171–178. doi.org/10.1016/j.sbi.2019.03.003. (PR) 
20. König S, Zhang Y, Wandall HH, Mussolino C, Bennett EP (2019): Fast and quantitative identification of ex vivo precise genome targeting induced indel events by IDAA. Methods Mol Biol. 1961:45-66. doi: 10.1007/978-1-4939-9170-9_4. (CO, PR)
21. Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, Ratheesh A, Reis-Rodrigues P, Shkarina K, Larsen ISB, Vakhrushev SY, Clausen H, Siekhaus DE.  (2019): A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Elife. 8. pii: e41801. doi: 10.7554/eLife.41801. (CO, PR)
22. Eiberg H, Mikkelsen AF, Bak M, Tommerup N, Lund AM, Wenzel A, Sabarinathan R, Gorodkin J, Bang-Berthelsen CH, Hansen L (2019): A splice-site variant in the lncRNA gene RP1-140A9.1 cosegregates in the large Volkmann cataract family. Mol Vis. 25:1-11. eCollection 2019.
23. de Las Rivas M, Lira-Navarrete E, Gerken TA, Hurtado-Guerrero R (2019): Polypeptide GalNAc-Ts: from redundancy to specificity. Curr Opin Struct Biol. 56:87-96. DOI: 10.1016/j.sbi.2018.12.007. (CO, PR)
24. Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Campos D, Halim A, Vakhrushev SY, Joshi H, Schreiber H, Mandel U, Narimatsu Y (2019): A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody. Glycobiology 2019 Feb 6. doi: 10.1093/glycob/cwz004. (CO, PR)

1. Nielsen MI, Stegmayr J, Grant OC, Yang Z, Nilsson UJ, Boos I, Carlsson MC, Woods RJ, Unverzagt C, Leffler H, Wandall HH (2018) Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context. J Biol Chem. 293:20249-20262. DOI: 10.1074/jbc.RA118.004636

2. Huang Y, Huang S, Di Scala C, Wang Q, Wandall HH, Fantini J, Zhang YQ (2018) The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt. Elife. 7. DOI: 10.7554/eLife.38183

3. Narimatsu H, Kaji H, Vakhrushev SY, Clausen H, Zhang H, Noro E, Togayachi A, Nagai-Okatani C, Kuno A, Zou X, Cheng L, Tao SC, Sun Y (2018): Current technologies for complex glycoproteomics and their applications to biology/disease-driven glycoproteomics. J Proteome Res. DOI: 10.1021/acs.jproteome.8b00515 [Epub ahead of print] 
   
   
4. Hintze J, Ye Z, Narimatsu Y, Madsen TD, Joshi H, Linstedt A, Bachert C, Mandel U, Bennett EP, Vakhrushev SY, Schjoldager KT (2018): Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines. J Biol Chem DOI: 10.1074/jbc.RA118.004516 [Epub ahead of print] 
   
   

5. de las Rivas M, Daniel EJP, Coelho H, Lira-Navarrete E, Raich L, Compañón I, Diniz A, Lagartera L, Jiménez-Barbero, Clausen H, Rovira C, Marcelo F, Corzana F, Gerken TA, Hurtado-Guerrero R. (2018): Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4. ACS Cent Sci. 4:1274-1290. DOI: 10.1021/acscentsci.8b00488

6. Nygaard MB, Herlihy AM, Jeanneau C, Nielsen JE, Bennett EP, Jørgensen N, Clausen H, Mandel U, Meyts ER & Almstrup K (2018): Expression of the O-Glycosylation Enzyme GalNAc-T3 in the Equatorial Segment Correlates with the Quality of Spermatozoa. Int J Mol Sci 19, 2949. DOI:10.3390/ijms19102949
   

7. Mathiesen CBK, Carlsson MC, Brand S, Möller SR, Idorn M, Straten PT, Pedersen AE, Dabelsteen S, Halim A, Würtzen PA, Brimnes J, Ipsen H, Petersen BL, Wandall HH (2018): Genetically engineered cell factories produce glycoengineered vaccines that target antigen presenting cells and reduce antigen specific T-cell reactivity. J Allergy Clin Immunol Aug 17. DOI: 10.1016/j.jaci.2018.07.030 (Epub ahead of print)
   
   

8. Caval T, Zhu J, Tian W, Remmelzwaal SN, Yang Z, Clausen H, Heck AJR (2018): Targeted analysis of lysosomal directed proteins and their sites of mannose-6-phosphate modification. Mol Cell Proteomics Sep 20. DOI: 10.1074/mcp.RA118.000967

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9. Caval T, Tian W, Yang Z, Clausen H & Heck AJ (2018): Direct quality control of glycoengineered erythropoietin variants. Nat Commun 9: 3342. DOI: 10.1038/s41467-018-05536-3

10. Chen Y-H, Narimatsu Y, Clausen TM, Gomes C, Karlsson R, Steentoft C, Spliid CB, Gustavsson T, Salanti A, Persson A, Malmström A, Willén W, Ellervik U, Bennett EP, Mao Y, Clausen H & Yang Z (2018): The GAGOme: a cell-based library of displayed glycosaminoglycans. Nat methods (Epub ahead of print). DOI: 10.1038/s41592-018-0086-z

11. Mathiesen CBK, Carlsson MC, Brand S, Möller SR, Idorn M, Straten PT, Pedersen AE, Dabelsteen S, Halim A, Würtzen PA, Brimnes J, Ipsen H, Petersen BL, Wandall HH. (2018). Genetically engineered cell factories produce glycoengineered vaccines that target antigen presenting cells and reduce antigen specific T-cell reactivity. J Allergy Clin Immunol Aug 17. DOI: 10.1016/j.jaci.2018.07.030

12. Lamriben L, Oster ME, Tamura T, Tian W, Yang Z, Clausen H, Hebert DN (2018): EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner and possesses catalytic activity. J Biol Chem July (Epub ahead of print). DOI:10.1074/jbc.RA118.004183

13. Coelho R, Marcos-Silva L, Mendes N, Pereira D, Brito C, Jacob F, Steentoft C, Mandel U, Clausen H, David L, Ricardo S. (2018 ): Mucins and Truncated O-Glycans Unveil Phenotypic Discrepancies between Serous Ovarian Cancer Cell Lines and Primary Tumours. Int J Mol Sci 19. DOI: 10.3390/ijms19072045

14. Davidsen J, Larsen S, Coskun M, Gögenur I, Dahlgaard K, Bennett EP, Troelsen JT (2018): The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2. PLoS One Jul 5;13(7):e0200215. DOI: 10.1371/journal.pone.0200215

15. King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev S, Schjoldager K, Overall CM, Wandall HH (2018): TAILS N-Terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation. J Biol Chem. May 18;293(20):7629-7644. DOI: 10.1074/jbc.RA118.001978

16. De Las Rivas M, Coelho H, Diniz A, Lira-Navarrete E, Compañón I, Jiménez-Barbero J, T Schjoldager K, P Bennett E, Y Vakhrushev S, Clausen H, Corzana F, Marcelo F, Hurtado-Guerrero R (2018): Structural analysis of a GalNAc-T2 mutant reveals an induced-fit catalytic mechanism for GalNAc-Ts. Chemistry Jun 12;24(33):8382-8392. DOI:10.1002/chem.201800701

17. Schulz MA, Tian W, Mao Y, van Coillie  J, Sun L, Larsen JS, Chen YH, Kristensen C, Vakhrushev SY, Clausen H, Yang Z. (2018). Glycoengineering design options for IgG1 in CHO cells using precise gene editing. Glycobiology Jul 1;28(7):542-549.
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18. Bagdonaite I, Wandall HH (2018): Global Aspects of Viral Glycosylation. Glycobiology Jul 1;28(7):443-467. DOI: 10.1093/glycob/cwy021

19. Wang S, Mao Y, Narimatsu Y, Ye Z, Tian W, Goth CK, Lira-Navarrete E, Pedersen NB, Benito-Vicente A, Martin C, Uribe KB, Hurtado-Guerrero R, Christoffersen C, Seidah NG, Nielsen R, Christensen EI, Hansen L, Bennett EP, Vakhrushev SY, Schjoldager KT, Clausen H. 2018. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. J Biol Chem May 11;293(19):7408-7422. DOI: 10.1074/jbc.M117.817981 

20. Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett EP, Wandall HH, Clausen H, Schjoldager KT. (2018): Glycosyltransferase Genes That Cause Monogenic Congenital Disorders of Glycosylation Are Distinct From Glycosyltransferase Genes Associated with Complex Diseases. Glycobiology, May 1;28(5):284-294. DOI: 10.1093/glycob/cwy015

21. Narimatsu Y, Joshi HJ, Zhang Y, Gomes C, Chen YH, Lorenzetti F, Furukawa S, Schjoldager K, Hansen L, Clausen H, Bennett EP, Wandall HH (2018): A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome. Glycobiology May 1;28(5):295-305. DOI: 10.1093/glycob/cwx101
    
    
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23. Joshi HJ, Narimatsu Y, Schjoldager KT-G, Tytgat HLP, Aebi M, Clausen H, Halim A. (2018). SnapShot: O-Glycosylation Pathways across Kingdoms. Cell 172:632–632. DOI: 10.1016/j.cell.2018.01.016.
    
    
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2. Rivas ML, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R. (2017). The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nat Commun. 8:1959. DOI: 10.1038/s41467-017-02006-0
   
   
3. Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH. (2017). De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium. J Biol Chem. pii: jbc.M117.812826. DOI: 10.1074/jbc.M117.812826
   
   
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11. Hansen LH, Darkner S, Svendsen JH, Henningsen K, Pehrson S, Chen X, Vakhrushev SY, Schjoldager KT, Goetze JP. Chromogranin A in the mammalian heart: expression without secretion. Biomark Med. 2017 11:541-545. DOI: 10.2217/bmm-2017-0052
    
    
12. Gipson IK, Mandel U, Menon B, Michaud S, Tisdale A, Campos D, Clausen H. (2017) Generation and characterization of a monoclonal antibody to the cytoplasmic tail of MUC16. Glycobiology 30:1-7. DOI: 10.1093/glycob/cwx054
    
    
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12. Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R. (2014) Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2. Angew Chem Int Ed Engl 53:8206-10. DOI: 10.1002/anie.201402781
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10. Pedersen JW, Gentry-Maharaj A, Nøstdal A, Fourkala EO, Dawnay A, Burnell M, Zaikin A, Burchell J, Papadimitriou JT, Clausen H, Jacobs I, Menon U, Wandall HH. (2013) Cancer associated auto-antibodies to MUC1 and MUC4 - A blinded case control study of colorectal cancer in UK collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Int J Cancer 134:2180-2188. DOI: 10.1002/ijc.28538
11. Gomes C, Almeida A, Ferreira JA, Silva L, Santos-Sousa H, Pinto-de-Sousa J, Santos LL, Amado F, Schwientek T, Levery S, Mandel U, Clausen H, David L, Reis CA, Osorio H. (2013) Glycoproteomic analysis of serum from patients with gastric precancerous lesions. J Proteome Res 12:1454-1466. DOI: 10.1021/pr301112x .
12. Vester-Christensen MB, Halim A, Joshi HJ, Steentoft C, Bennett EP, Levery SB, Vakhrushev SY, Clausen H. (2013) Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins. Proc Natl Acad Sci USA 110:21018-21023. DOI: 10.1073/pnas.1313446110
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14. Chen K, Gentry-Maharaj A, Burnell M, Steentoft C, Marcos-Silva L, Mandel U, Jacobs I, Dawnay A, Menon U, Blixt O. (2013) Microarray Glycoprofiling of CA125 improves differential diagnosis of ovarian cancer. J Proteome Res 12:1408-1418. DOI: 10.1021/pr3010474 .
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11. Sørensen AL, Clausen H, Wandall HH. (2012) Carbohydrate clearance receptors in transfusion medicine. Biochim Biophys Acta 1820:1797-1808. DOI: 10.1016/j.bbagen.2012.07.008
12. Stuchlová Horynová M, Raška M, Clausen H, Novak J. (2012) Aberrant O-glycosylation and anti-glycan antibodies in an autoimmune disease IgA nephropathy and breast adenocarcinoma. Cell Mol Life Sci 70:829-39. Epub 2012. DOI: 10.1007/s00018-012-1082-6
13. Schjoldager KT, Clausen H. (2012) Site-specific protein O-glycosylation modulates proprotein processing - Deciphering specific functions of the large polypeptide GalNAc-transferase gene family. Biochim Biophys Acta 1820:2079-2094. DOI: 10.1016/j.bbagen.2012.09.014
14. Pincus SH, Moran E, Maresh G, Jennings HJ, Pritchard DG, Egan ML, Blixt O. (2012) Fine specificity and cross-reactions of monoclonal antibodies to group B streptococcal capsular polysaccharide type III. Vaccine 30:4849-4858. DOI: 10.1016/j.vaccine.2012.05.006
15. Cló E, Kracun SK, Nudelman AS, Jensen KJ, Liljeqvist JÅ, Olofsson S, Bergström T, Blixt O. (2012) Characterization of the viral O-glycopeptidome: a novel tool of relevance for vaccine design and serodiagnosis. J Virol 86:6268-5278. DOI: 10.1128/JVI.00392-12
16. Shilova N, Navakouski M, Khasbiullina N, Blixt O, Bovin N. (2012) Printed glycan array: antibodies as probed in undiluted serum and effects of dilution. Glycoconj J 29:87-91. DOI: 10.1007/s10719-011-9368-8
17. Blixt O, Lavrova OI, Mazurov DV, Cló E, Kracun SK, Bovin NV, Filatov AV. (2012) Analysis of Tn antigenicity with a panel of new IgM and IgG1 monoclonal antibodies raised against leukemic cells. Glycobiology 22:529-542. DOI: 10.1093/glycob/cwr178
18. Chen LM, Blixt O, Stevens J, Lipatov AS, Davis CT, Collins BE, Cox NJ, Paulson JC, Donis RO. (2012) In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity. Virology 422:105-113. DOI: 10.1016/j.virol.2011.10.006
19. Herrmann A, König S, Lechtenberg M, Sehlbach M, Vakhrushev SY, Peter-Katalinic J, Hensel A. (2012) Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein. Glycobiology 22:1424-1439. DOI: 10.1093/glycob/cws107
20. Klimmeck D, Hansson J, Raffel S, Vakhrushev SY, Trumpp A, Krijgsveld J. (2012) Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells. Mol Cell Proteomics 11:286-302. DOI: 10.1074/mcp.M111.016790
21. Adlercreutz D, Yoshimura Y, Mannerstedt K, Wakarchuk WW, Bennett EP, Dovichi NJ, Hindsgaul O, Palcic MM. (2012) Thiogalactopyranosides are resistant to hydrolysis by α-galactosidases. Chembiochem 13:1673-1679. DOI: 10.1002/cbic.201200155
22. Kragelund C, Kieffer-Kristensen L, Reibel J, Bennett EP. (2013) Oral candidosis in lichen planus: the diagnostic approach is of major therapeutic importance. Clin Oral Investig 17:957-965, Epub 2012 Jun. DOI: 10.1007/s00784-012-0757-6
23. Castro I, Aguilera S, Brockhausen I, Alliende C, Quest AF, Molina C, Urzúa U, Mandel U, Bahamondes V, Barrera MJ, Sánchez M, González S, Hermoso M, Leyton C, González MJ. (2012) Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren's syndrome patients. Rheumatology (Oxford). 51:482-490. DOI: 10.1093/rheumatology/ker351
24. Kjærulff O, Wandall H. (2012). Neurofibromatosis 1: pathogenesis and therapeutic strategies--a systematic review. Ugeskr Laeger 174:642-647.
25. Blixt O, Boos I, Mandel U. (2012) Glycan Microarray Analysis of Tumor-Associated Antibodies; in Anticarbohydrate Antibodies. Editor P. Kosma, Springer Verlag

Flintegaard TV, Thygesen P, Rahbek-Nielsen H, Levery SB, Kristensen C, Clausen H, Bolt G (2010) N-glycosylation increases the circulatory half-life of human growth hormone. Endocrinology. 2010 November;151(11):5326-36.

Schjoldager KT, Vester-Christensen MB, Bennett EP, Levery SB, Schwientek T, Yin W, Blixt O, Clausen H (2010). O-glycosylation Modulates Proprotein Convertase Activation of Angiopoietin-Like Protein 3 - Possible Role of GALNT2 in Regulation of HDL and TG. J Biol Chem. 2010 November 19;285(47)36293-303
 
Podbielska M, Dasgupta S, Levery SB, Tourtellotte WW, Annuk H, Moran AP, *Hogan EL (2010).  Novel myelin penta- and hexa-acetyl-galactosyl-ceramides: Structural characterization and immunoreactivity in cerebrospinal fluid.  J Lipid Res, 51: 1394-1406.

Li Y, Arigi EA, Eichert H, *Levery SB (2010). Mass spectrometry of fluorocarbon-labeled glycosphingolipids. J Mass Spectrom, 45: 504-519.

Sulzenbacher G, Liu QP, Yuan H, Bennett EP, Levery SB, Bourne Y, Ponchel G, Clausen H, Henrissat B (2010). A novel -N-acetylgalactosaminidase family with an NAD+-dependent catalytic mechanism suitable for enzymatic removal of blood group A antigens. Biocatalysis and Biotransformation 28:22-32.

Cló, E; Blixt, O; Jensen, JK.  (2010) Chemoselective Reagents for Covalent Capture and Display of Glycans in Microarrays. European Journal of Organic Chemistry 3, 540-554

Wandall, HH.; Blixt, O.; Tarp, MA.; Pedersen, JW.; Bennett, EP.; Mandel, U.; Ragupathi, G, Livingston, PO, Hollingsworth, MA, Taylor-Papadimitriou, J, Burchell, J, Clausen, H. (2010) Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes. Cancer Res, 70, (4), 1306-13

Blixt, O, Clo, E, Nudelman, AS, Sørensen, KK, Clausen, T, Wandall, HH, Livingston, PO, Clausen, H, Jensen, K J (2010) A High-throughput O-Glycopeptide Discovery Platform for Seromic Profiling J Proteome Res. 2010 Oct 1;9(10):5250-61.
 
Kracun, SK., Cló, E, Clausen, H, Levery, SB, Jensen, JK, Blixt, O (2010) Random Glycopeptide Bead Libraries for Seromic Biomarker Discovery. J Proteome Res. 2010 Dec 3;9(12):6705-14

Blixt, O, Bueti, D, Burford, B, Allen, D, Julien, S, Clausen, H, Hollingsworth, MA, Gammerman, A, Fentiman, IS, Taylor-Papadimitriou, J, Burchell, J (2010) Presence of autoantibodies to aberrantly glycosylated MUC1 in breast cancer patients is associated with disease progression. Breast Cancer Res. 2011 Mar 8;13(2):R25.

Steentoft, C.; Schjoldager, K.; Clo, E.; Mandel, U.; Levery, S. B.; Pedersen, J. W.; Jensen, K.; Blixt, O.; Clausen, H., Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8). Glycoconj J. 2010 Aug;27(6):571-82.

Picco, G., Julien, S., Brockhausen, I., Beatson, R., Antonopoulos, A., Haslam, S., Mandel, U., Dell, A., Pinder, S., Taylor-Papadimitriou, J., Burchell, J. Over-expression of ST3Gal-I promotes mammary tumorigenesis. Glycobiology. 2010 Oct; 20(10):1241-50. 2010.

Bennett, E.P., Chen, Y., W., Schwientek, T., Mandel, U., Schjoldager, K.B., Cohen, S.M., Clausen, H. Rescue of Drosophila Melanogaster I(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11. Glycoconj J. 2010 May; 27(4):435-44.  2010.

Kato, K., Takeuchi, H., Kanoh, A., Miyahara, N., Nemoto-Sasaki, Y., Morimoto-Tomita, M., Matsubara, A., Ohashi, Y., Waki, M., Usami, K., Mandel, U., Clausen, H., Higashi, N., Irimura, T. Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis. Glycoconj J, 27: 267-76, 2010.